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Friday, July 17, 2020 | History

1 edition of The use of indomethacin in treatment of the patent ductus arteriosus in premature infants found in the catalog.

The use of indomethacin in treatment of the patent ductus arteriosus in premature infants

a review of the literature and the Yale experience

by Marc Glickstein

  • 387 Want to read
  • 17 Currently reading

Published by s.n.] in [New Haven .
Written in English

    Subjects:
  • Infants (Premature),
  • Ductus arteriosus

  • Edition Notes

    StatementMarc Glickstein
    The Physical Object
    Pagination82 leaves ;
    Number of Pages82
    ID Numbers
    Open LibraryOL26393011M
    OCLC/WorldCa689724897

    Patent ductus arteriosus (PDA) is a heart defect found in the days or weeks after birth. The ductus arteriosus is a normal part of fetal blood circulation. All babies are born with this opening between the aorta and the pulmonary artery. But it usually closes on its own shortly after birth. If it stays open, it is called patent ductus arteriosus.   Jaillard S, Larrue B, Rakza T, Magnenant E, Warembourg H, Storme L. Consequences of delayed surgical closure of patent ductus arteriosus in very premature infants.

      The patency of ductus arteriosus (PDA) is a frequent complication in preterm infants with respiratory distress syndrome (RDS), and 60–70% of preterm infants of ductus as a complication of RDS have higher respiratory failure rates, lower survival rates, and increased risk of.   Effects of indomethacin in premature infants with patent ductus arteriosus: results of a national collaborative study. J Pediatr. Jun;(6) Layout table for additonal information.

    study, anecdotal case reports, from other studies using rectal, oral, or intravenous indomethacin for treatment of patent ductus arteriosus or in marketed use. The rates are calculated from a database which contains experience of indomethacin-treated neonates reported in the medical literature, regardless of the route of administration.   We hypothesize that feeding preterm infants while they receive indomethacin or ibuprofen therapy for treatment of a patent ductus arteriosus will decrease the incidence of feeding intolerance and shorten the time period that infants need to tolerate full enteral nutrition.


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The use of indomethacin in treatment of the patent ductus arteriosus in premature infants by Marc Glickstein Download PDF EPUB FB2

Background: Indomethacin is used as standard therapy to close a patent ductus arteriosus (PDA) but is associated with reduced blood flow to several organs. Ibuprofen, another cyclo-oxygenase inhibitor, may be as effective as indomethacin with fewer side effects.

Objectives: To determine the effectiveness and safety of ibuprofen compared to placebo or no intervention for closing a PDA in Cited by:   Clinical Epidemiology and Natural History of Patent Ductus Arteriosus.

In term infants, the ductus arteriosus normally constricts after birth and becomes functionally closed by 72 hours of age. 2 In preterm infants, however, closure is delayed, remaining open at 4 days of age in approximately 10% of infants born at 30 through 37 weeks’ gestation, 80% of those born at 25 through 28 weeks Cited by: Background: A patent ductus arteriosus (PDA) often complicates the clinical course of preterm infants and increases the risk of intraventricular hemorrhage (IVH), necrotizing enterocolitis (NEC), chronic lung disease (CLD) and death.

The standard treatment to close a PDA is indomethacin. Its use is associated with renal, gastrointestinal and cerebral by:   Ibuprofen for the treatment of patent ductus arteriosus in preterm and/or low birth weight infants. Cochrane Database Syst Rev. Apr 4:CD [Medline]. We report an infant who developed hypertension after indomethacin use for patent ductus arteriosus.

The patient was delivered at 31 weeksʼ gestation. Patent ductus arteriosus was detected on day 2. Indomethacin is a non-steroidal anti-inflammatory drug that is a potent inhibitor of prostaglandin E(2) synthesis.

After birth, the ductus arteriosus closes spontaneously within days in term infants. The major factor closing the ductus arteriosus is the tension of. 1. Introduction. Hemodynamically significant patent ductus arteriosus (hsPDA) is one of the most common problems in premature infants.

Many studies have shown that cyclooxygenase (COX) inhibitors [indomethacin, ibuprofen (IBU)]1, 2, 3 and surgical closure 4 are effective in closing the ductus arteriosus in premature infants.

However, the debate is ongoing about the selection of the treatment. known because of widespread use of treatments to achieve closure of the patent ductus arteriosus (PDA) in such infants.

Data from placebo arms of controlled trials demonstrate that spontaneous ductal closure in these infants is frequent, however. In the Trial of Indomethacin Prophylaxis. Prophylactic indomethacin therapy for patent ductus arteriosus in very-low-birth-weight infants.

N Engl J Med. Mar 4; (9)– Gersony WM, Peckham GJ, Ellison RC, Miettinen OS, Nadas AS. Effects of indomethacin in premature infants with patent ductus arteriosus: results of a national collaborative study. J Pediatr. Patent ductus arteriosus, or PDA, is a congenital heart defect common in premature babies in which the ductus arteriosus (a vessel connecting the pulmonary artery to the descending aorta) fails to close.

Patent Ductus Arteriosus (PDA) Page 4 of 4 Neonatal Guideline 9. Shaffer, C.L., et al., Effect of age and birth weight on indomethacin pharmacodynamics in neonates treated for patent ductus arteriosus.

Critical Care Medicine, 30(2): p. - Noori, S., Pros and cons of patent ductus arteriosus ligation: hemodynamic changes and other. Background Indomethacin is the conventional treatment for patent ductus arteriosus in preterm infants. However, its use is associated with various side effects.

In a prospective study, we compared. The patent ductus arteriosus (PDA) is a significant remnant of fetal circulation which may contribute to common morbidities in premature infants.

While the presence of the ductus arteriosus is necessary for the fetus, serving as a pathway for oxygenated blood from the placenta to bypass the lungs and enter the systemic circulation, it can.

Patent ductus arteriosus (PDA) is a common diagnosis among extremely premature infants, especially in those with lung disease. Treatments are often used to close the PDA.

Despite nearly three decades of research, the question of whether the benefits of treatments to prevent ductal patency or promote closure outweigh the risks of these treatments remains unanswered. The authors rarely use.

In preterm newborns, the ductus arteriosus frequently fails to close and the infants require medical or surgical closure of the patent ductus arteriosus (PDA).

A PDA can be treated surgically; or medically with one of two prostaglandin inhibitors, indomethacin or ibuprofen. Gersony WM, Peckham GJ, Ellison RC, et al. Effects of indomethacin in premature infants with patent ductus arteriosus: results of a national collaborative study. J Pediatr ; Bagnoli F, Rossetti A, Messina G, et al.

Treatment of patent ductus arteriosus (PDA) using ibuprofen: renal side-effects in VLBW and ELBW newborns. Ohlsson A, Walia R, Shah S. Ibuprofen for the treatment of patent ductus arteriosus in preterm and/or low birth weight infants.

Cochrane Database Syst Rev. Jan CD Review question. Is the use of ibuprofen compared with indomethacin, other cyclo-oxygenase inhibitors, placebo, or no intervention for closing a patent ductus arteriosus (PDA) safe and effective for improving the rate of ductal closure and other important clinical outcomes in preterm or low-birth-weight (or both) infants.

Background. A common complication for very preterm (premature) or very. The ductus arteriosus allows most of the blood to bypass the lungs and go the rest of the body. After birth, the baby must use his/her lungs to take in oxygen and get rid of carbon dioxide.

Now, the blood from the pulmonary artery needs to go to the lungs to pick up oxygen instead of going through the ductus arteriosus. The ductus arteriosus (DA) is a temporary communicative pathway that connects the pulmonary artery to the aorta during fœtal life.

Although usually closing on its own in the initial days of postnatal life, the persistent patency of the DA is common in preterm or low birth weight babies, and can lead to life-threatening complications. Early diagnosis and pharmacologic management of patent.

Background. Patent ductus arteriosus (PDA) remains a critical issue in prematurity care. To predict the PDA closure early, we aimed to clarify the association of PDA closure with the initial postnatal hour clinical characteristics and maternal and gestational histories of preterm neonates.

Indomethacin and ibuprofen are the two most commonly used drugs for closing a hemodynamically significant ductus in the neonate.

Prophylactic indomethacin reduces the risk of patent ductus arteriosus, intraventricular hemorrhage, and pulmonary hemorrhage but does not improve the rate of survival without neurosensory impairment at 18 months.Indomethacin is the conventional treatment for hemodynamically important patent ductus arteriosus in preterm infants.

However, its use is associated with various side effects.